Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model

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Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model.

Neural transplantation in experimental Parkinsonism has so far focused on the ectopic placement of fetal ventral mesencephalic (VM) neurons into the dopamine-denervated caudate-putamen. VM grafts are effective in restoring dopamine neurotransmission in the grafted caudate-putamen and in partial amelioration of behavioral deficits. Recent pharmacological and physiological data have provided stro...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1994

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.14-06-03449.1994